منابع مشابه
Safety-Catch and Multiply Cleavable Linkers in Solid- Phase Synthesis
This review article focuses on concepts that incorporate safety-catch and multiply cleavable linkers in solid-phase synthesis. Discussed are specific applications of such linkers in the synthesis of peptides, peptide mimetics, and “small” organic molecules, as well as their limitations for particular chemistries and reaction conditions. © 1999 John Wiley & Sons, Inc. Biopoly 47: 353–363, 1998
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A N-benzyl-4-amino-2,2-dimethylbutanoic acid-based system has been developed as a new oxidatively activated safety catch linker for reaction monitoring and optimisation on solid support. The CAN promoted oxidative debenzylation of the tertiary N-benzylamine moiety, followed by concomitant cyclisation and release of alcohols and amines has been demonstrated both in solution phase model studies a...
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Diarrhea is one of the most common concerns of veterinarians evaluating kittens with a health problem. Often times, diarrhea in kittens can be attributed to dietary changes, parasites or infectious diseases, and these should be the focus of any investigation in these young cats. Adult cats often have different and more chronic causes of diarrhea than kittens, but the condition remains a common ...
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The ClpXP protease of bacteria can degrade a wide variety of proteins while maintaining remarkable substrate selectivity. New work in Escherichia coli implicates adaptor proteins in enhancing substrate selectivity and regulating the flow of substrates to cellular proteases.
متن کاملSonographic evaluation of experimental hydrocephalus in kittens.
Real-time computed sonography was used to monitor ventricular size in kittens with experimentally induced hydrocephalus. Hydrocephalus was induced by cisternal kaolin injection in newborn kittens in order to study the effects of both hydrocephalus and subsequent ventriculoperitoneal shunting on the morphology of brain tissue. When severe hydrocephalus was achieved, marked physical and neurologi...
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ژورنال
عنوان ژورنال: Nature
سال: 2007
ISSN: 0028-0836,1476-4687
DOI: 10.1038/450362b